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CG method and four other methods to determine eCLcr, with inulin clearance being considered the standard measure of GFR. Half of patients receiving nifurtimox will discontinue therapy due to adverse effects, which include gastrointestinal disturbances anorexia, nausea, vomiting , CNS toxicity headache, vertigo, insomnia , myalgias, and peripheral neuropathy. Which of the following is a component of the neurologic examination? Amiodarone is an amphiphilic molecule that contains both a highly apolar aromatic ring system and a polar side chain with a positively charged nitrogen atom.


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Two factors affecting the absorption of drugs from the gastrointestinal tract are pH-dependent passive diffusion and gastric emptying time. Patients with known G6PD enzyme deficiencies should be advised to avoid medications capable of inducing the hemolysis. Even drugs that are not normally used topically may be systemically absorbed. The patient may have no hypoxic symptoms, for example, angina while resting, but it may become quite evident when the patient begins to exercise. Hepatomegaly and jaundice sometimes may be evident.

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However, some cases require different dosing and selection of medications. This chapter provides an overview of nausea and vomiting, two multifaceted problems. Risk factors associated with worsening glucose tolerance included female sex and elevated baseline insulin values.

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